Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma

The C-X-C chemokine receptor type 4 (CXCR4) is a pleiotropic chemokine receptor that is expressed in not only normal hematopoietic cells but also multiple myeloma cells. Its ligand, stromal cell-derived factor 1α (SDF-1α) is produced in the bone marrow microenvironment. The SDF-1α/CXCR4 axis plays a...

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Main Authors:	Shigeki Ito, Tsuyoshi Sato, Takahiro Maeta
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	Cancers
Subjects:	CXCR4 SDF-1α multiple myeloma drug resistance extramedullary disease
Online Access:	https://www.mdpi.com/2072-6694/13/8/1793

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spelling	doaj-b66bef31a2374691af88bfcbec2639312021-04-09T23:02:09ZengMDPI AGCancers2072-66942021-04-01131793179310.3390/cancers13081793Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple MyelomaShigeki Ito0Tsuyoshi Sato1Takahiro Maeta2Division of Hematology & Oncology, Department of Internal Medicine, Iwate Medical University School of Medicine, Yahaba 028-3695, JapanDivision of Hematology & Oncology, Department of Internal Medicine, Iwate Medical University School of Medicine, Yahaba 028-3695, JapanDivision of Hematology & Oncology, Department of Internal Medicine, Iwate Medical University School of Medicine, Yahaba 028-3695, JapanThe C-X-C chemokine receptor type 4 (CXCR4) is a pleiotropic chemokine receptor that is expressed in not only normal hematopoietic cells but also multiple myeloma cells. Its ligand, stromal cell-derived factor 1α (SDF-1α) is produced in the bone marrow microenvironment. The SDF-1α/CXCR4 axis plays a pivotal role in the major physiological processes associated with tumor proliferation, survival, invasion, dissemination, and drug resistance in myeloma cells. This review summarizes the pleiotropic role of the SDF-1α/CXCR4 axis in multiple myeloma and discusses the future perspective in the SDF-1α/CXCR4 axis-targeted therapies in multiple myeloma.https://www.mdpi.com/2072-6694/13/8/1793CXCR4SDF-1αmultiple myelomadrug resistanceextramedullary disease
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Shigeki Ito Tsuyoshi Sato Takahiro Maeta
spellingShingle	Shigeki Ito Tsuyoshi Sato Takahiro Maeta Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma Cancers CXCR4 SDF-1α multiple myeloma drug resistance extramedullary disease
author_facet	Shigeki Ito Tsuyoshi Sato Takahiro Maeta
author_sort	Shigeki Ito
title	Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma
title_short	Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma
title_full	Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma
title_fullStr	Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma
title_full_unstemmed	Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma
title_sort	role and therapeutic targeting of sdf-1α/cxcr4 axis in multiple myeloma
publisher	MDPI AG
series	Cancers
issn	2072-6694
publishDate	2021-04-01
description	The C-X-C chemokine receptor type 4 (CXCR4) is a pleiotropic chemokine receptor that is expressed in not only normal hematopoietic cells but also multiple myeloma cells. Its ligand, stromal cell-derived factor 1α (SDF-1α) is produced in the bone marrow microenvironment. The SDF-1α/CXCR4 axis plays a pivotal role in the major physiological processes associated with tumor proliferation, survival, invasion, dissemination, and drug resistance in myeloma cells. This review summarizes the pleiotropic role of the SDF-1α/CXCR4 axis in multiple myeloma and discusses the future perspective in the SDF-1α/CXCR4 axis-targeted therapies in multiple myeloma.
topic	CXCR4 SDF-1α multiple myeloma drug resistance extramedullary disease
url	https://www.mdpi.com/2072-6694/13/8/1793
work_keys_str_mv	AT shigekiito roleandtherapeutictargetingofsdf1acxcr4axisinmultiplemyeloma AT tsuyoshisato roleandtherapeutictargetingofsdf1acxcr4axisinmultiplemyeloma AT takahiromaeta roleandtherapeutictargetingofsdf1acxcr4axisinmultiplemyeloma
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Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma

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