TRPS1 drives heterochromatic origin refiring and cancer genome evolution

TRPS1 drives heterochromatic origin refiring and cancer genome evolution

Summary: Exploitation of naturally occurring genetic mutations could empower the discovery of novel aspects of established cancer genes. We report here that TRPS1, a gene linked to the tricho-rhino-phalangeal syndrome (TRPS) and recently identified as a potential breast cancer driver, promotes breas...

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Bibliographic Details
Main Authors: Jianguo Yang, Xiaoping Liu, Yunchao Huang, Lin He, Wenting Zhang, Jie Ren, Yue Wang, Jiajing Wu, Xiaodi Wu, Lin Shan, Xiaohan Yang, Luyang Sun, Jing Liang, Yu Zhang, Yongfeng Shang
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Cell Reports
Subjects:
heterochromatic origin refiring
TRPS1
H3K9me3
breast cancer
cancer genome evolution
therapeutic resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721001285

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