Study of antinociceptive effects on acute pain treated by bioactive fractions of Hyptis suaveolens
Objective: To investigate the ethanolic extract and its fractions of Hyptis suaveolens (H. suaveolens) for antinociceptive and central nervous system depressant effects. Methods: Dried and coarsely powdered aerial parts of plant material were extracted in 80% aqueous ethanol. Further extract was...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2016-09-01
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| Series: | Journal of Acute Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2221618916301123 |
| Summary: | Objective: To investigate the ethanolic extract and its fractions of Hyptis suaveolens
(H. suaveolens) for antinociceptive and central nervous system depressant effects.
Methods: Dried and coarsely powdered aerial parts of plant material were extracted in
80% aqueous ethanol. Further extract was fractionated using solvents of varying polarity.
Analgesic properties was assessed using acetic acid-induced writhing and hot plate test
and locomotor activity were performed in mice using hole board test.
Results: The petroleum ether and ethyl acetate extracts had produced significant analgesic properties and were found to be maximum when tested at 400 mg/kg. Both extracts
significantly increased the latency time in hot plate test and the action was antagonised by
naloxone. The naloxone was not able to alter H. suaveolens induced antinociceptive
effect in writhing test.
Conclusions: From the point of central nervous system depressant and good protective
effect on chemical and thermal pain stimuli, it indicates that H. suaveolens might have
resulted from activation of opioid and/or peripheral receptors. |
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| ISSN: | 2221-6189 |