Novel Kidney Auto Transplantation Technique for Ischemia-Reperfusion Studies

Novel Kidney Auto Transplantation Technique for Ischemia-Reperfusion Studies

Large animal studies of long-term ischemia reperfusion are hampered by the use of immunosuppressive drugs to inhibit the influence of the allogeneic response. In small animals, this can be controlled by using inbred strains of the animal. For obvious reasons, this is not possible in large animals su...

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Main Authors: Michael Olausson, Deepti Antony, Galina Travnikova, Debashish Banerjee, Goditha U. Premaratne
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Transplantology
Subjects:
kidney transplantation
ischemia reperfusion studies
pig model
auto transplantation
Online Access:https://www.mdpi.com/2673-3943/2/2/21
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spelling doaj-b651e13206614ed48eb19ddee6815ee42021-06-30T23:54:47ZengMDPI AGTransplantology2673-39432021-06-0122122422810.3390/transplantology2020021Novel Kidney Auto Transplantation Technique for Ischemia-Reperfusion StudiesMichael Olausson0Deepti Antony1Galina Travnikova2Debashish Banerjee3Goditha U. Premaratne4Department of Transplantation, Sahlgrenska Academy, University of Gothenburg University and the Sahlgrenska Transplant Institute at Sahlgrenska University Hospital, SE-41345 Göteborg, SwedenLaboratory for Transplantation and Regenerative Medicine, Sahlgrenska Academy at Gothenburg University and the Sahlgrenska Transplant Institute at Sahlgrenska University Hospital, SE-41345 Göteborg, SwedenLaboratory for Transplantation and Regenerative Medicine, Sahlgrenska Academy at Gothenburg University and the Sahlgrenska Transplant Institute at Sahlgrenska University Hospital, SE-41345 Göteborg, SwedenLaboratory for Transplantation and Regenerative Medicine, Sahlgrenska Academy at Gothenburg University and the Sahlgrenska Transplant Institute at Sahlgrenska University Hospital, SE-41345 Göteborg, SwedenLaboratory for Transplantation and Regenerative Medicine, Sahlgrenska Academy at Gothenburg University and the Sahlgrenska Transplant Institute at Sahlgrenska University Hospital, SE-41345 Göteborg, SwedenLarge animal studies of long-term ischemia reperfusion are hampered by the use of immunosuppressive drugs to inhibit the influence of the allogeneic response. In small animals, this can be controlled by using inbred strains of the animal. For obvious reasons, this is not possible in large animals such as pigs. Since studies in pigs usually are the last step before first-in-man studies, this remains a problem trying to resemble a clinical situation. In the following short paper, we describe a novel auto kidney transplantation model that can be used for long term ischemia reperfusion studies. We also suggest a control setting to balance out the possible influence of an increased surgical trauma.https://www.mdpi.com/2673-3943/2/2/21kidney transplantationischemia reperfusion studiespig modelauto transplantation
collection DOAJ
language English
format Article
sources DOAJ
author Michael Olausson
Deepti Antony
Galina Travnikova
Debashish Banerjee
Goditha U. Premaratne
spellingShingle Michael Olausson
Deepti Antony
Galina Travnikova
Debashish Banerjee
Goditha U. Premaratne
Novel Kidney Auto Transplantation Technique for Ischemia-Reperfusion Studies
Transplantology
kidney transplantation
ischemia reperfusion studies
pig model
auto transplantation
author_facet Michael Olausson
Deepti Antony
Galina Travnikova
Debashish Banerjee
Goditha U. Premaratne
author_sort Michael Olausson
title Novel Kidney Auto Transplantation Technique for Ischemia-Reperfusion Studies
title_short Novel Kidney Auto Transplantation Technique for Ischemia-Reperfusion Studies
title_full Novel Kidney Auto Transplantation Technique for Ischemia-Reperfusion Studies
title_fullStr Novel Kidney Auto Transplantation Technique for Ischemia-Reperfusion Studies
title_full_unstemmed Novel Kidney Auto Transplantation Technique for Ischemia-Reperfusion Studies
title_sort novel kidney auto transplantation technique for ischemia-reperfusion studies
publisher MDPI AG
series Transplantology
issn 2673-3943
publishDate 2021-06-01
description Large animal studies of long-term ischemia reperfusion are hampered by the use of immunosuppressive drugs to inhibit the influence of the allogeneic response. In small animals, this can be controlled by using inbred strains of the animal. For obvious reasons, this is not possible in large animals such as pigs. Since studies in pigs usually are the last step before first-in-man studies, this remains a problem trying to resemble a clinical situation. In the following short paper, we describe a novel auto kidney transplantation model that can be used for long term ischemia reperfusion studies. We also suggest a control setting to balance out the possible influence of an increased surgical trauma.
topic kidney transplantation
ischemia reperfusion studies
pig model
auto transplantation
url https://www.mdpi.com/2673-3943/2/2/21
work_keys_str_mv AT michaelolausson novelkidneyautotransplantationtechniqueforischemiareperfusionstudies
AT deeptiantony novelkidneyautotransplantationtechniqueforischemiareperfusionstudies
AT galinatravnikova novelkidneyautotransplantationtechniqueforischemiareperfusionstudies
AT debashishbanerjee novelkidneyautotransplantationtechniqueforischemiareperfusionstudies
AT godithaupremaratne novelkidneyautotransplantationtechniqueforischemiareperfusionstudies
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