General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins
Synthesis of peptides and proteins containing multiple disulfide bonds is challenging, limiting the elucidation of their biological functions. Here, the authors report a general synthetic strategy for fast formation of two and three disulfide bonds in peptides and proteins, and apply it to prepare s...
Main Authors: | Shay Laps, Fatima Atamleh, Guy Kamnesky, Hao Sun, Ashraf Brik |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-02-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-21209-0 |
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