General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins

Synthesis of peptides and proteins containing multiple disulfide bonds is challenging, limiting the elucidation of their biological functions. Here, the authors report a general synthetic strategy for fast formation of two and three disulfide bonds in peptides and proteins, and apply it to prepare s...

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Bibliographic Details
Main Authors: Shay Laps, Fatima Atamleh, Guy Kamnesky, Hao Sun, Ashraf Brik
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21209-0

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