General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins

General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins

Synthesis of peptides and proteins containing multiple disulfide bonds is challenging, limiting the elucidation of their biological functions. Here, the authors report a general synthetic strategy for fast formation of two and three disulfide bonds in peptides and proteins, and apply it to prepare s...

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Main Authors: Shay Laps, Fatima Atamleh, Guy Kamnesky, Hao Sun, Ashraf Brik
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21209-0
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spelling doaj-b650fa8fa31e44d7bc9a77cbbc106aff2021-02-14T12:13:10ZengNature Publishing GroupNature Communications2041-17232021-02-011211910.1038/s41467-021-21209-0General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteinsShay Laps0Fatima Atamleh1Guy Kamnesky2Hao Sun3Ashraf Brik4Schulich Faculty of Chemistry, Technion-Israel Institute of TechnologySchulich Faculty of Chemistry, Technion-Israel Institute of TechnologySchulich Faculty of Chemistry, Technion-Israel Institute of TechnologySchulich Faculty of Chemistry, Technion-Israel Institute of TechnologySchulich Faculty of Chemistry, Technion-Israel Institute of TechnologySynthesis of peptides and proteins containing multiple disulfide bonds is challenging, limiting the elucidation of their biological functions. Here, the authors report a general synthetic strategy for fast formation of two and three disulfide bonds in peptides and proteins, and apply it to prepare several therapeutically important peptides.https://doi.org/10.1038/s41467-021-21209-0
collection DOAJ
language English
format Article
sources DOAJ
author Shay Laps
Fatima Atamleh
Guy Kamnesky
Hao Sun
Ashraf Brik
spellingShingle Shay Laps
Fatima Atamleh
Guy Kamnesky
Hao Sun
Ashraf Brik
General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins
Nature Communications
author_facet Shay Laps
Fatima Atamleh
Guy Kamnesky
Hao Sun
Ashraf Brik
author_sort Shay Laps
title General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins
title_short General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins
title_full General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins
title_fullStr General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins
title_full_unstemmed General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins
title_sort general synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-02-01
description Synthesis of peptides and proteins containing multiple disulfide bonds is challenging, limiting the elucidation of their biological functions. Here, the authors report a general synthetic strategy for fast formation of two and three disulfide bonds in peptides and proteins, and apply it to prepare several therapeutically important peptides.
url https://doi.org/10.1038/s41467-021-21209-0
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AT fatimaatamleh generalsyntheticstrategyforregioselectiveultrafastformationofdisulfidebondsinpeptidesandproteins
AT guykamnesky generalsyntheticstrategyforregioselectiveultrafastformationofdisulfidebondsinpeptidesandproteins
AT haosun generalsyntheticstrategyforregioselectiveultrafastformationofdisulfidebondsinpeptidesandproteins
AT ashrafbrik generalsyntheticstrategyforregioselectiveultrafastformationofdisulfidebondsinpeptidesandproteins
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