Tobacco carcinogen research to aid understanding of cancer risk and influence policy

• Main Authors: Hitesh Singhavi, Jasjit S. Ahluwalia, Irina Stepanov, Prakash C. Gupta, Vikram Gota, Pankaj Chaturvedi, Samir S. Khariwala
• Format: Article
• Language: English
• Published: Wiley 2018-10-01
• Series: Laryngoscope Investigative Otolaryngology
• Subjects: Head and neck cancer; tobacco; carcinogen; nitrosamines; DNA adduct; Level of Evidence
• Online Access: https://doi.org/10.1002/lio2.204

Education regarding the health effects associated with tobacco use has made important progress worldwide over the last few decades. Still, tobacco remains a significant cause of cancer and other diseases. As a result, significant worldwide morbidity and mortality is still attributable to tobacco use in modern times. Research into tobacco products, the carcinogens they contain, and how users metabolize them is an important benefit to the advancement of research aimed at reducing harm associated with tobacco use. This review summarizes the use of this type of research to study tobacco users’ risk of developing cancer, especially head and neck cancer. In addition, we discuss the use of tobacco research to provide support for increasing levels of federal regulation of tobacco products. Level of Evidence 4.