Processing of Cells’ Trajectories Data for Blood Flow Simulation Model*

Simulations of the red blood cells (RBCs) flow as a movement of elastic objects in a fluid, are developed to optimize microfluidic devices used for a blood sample analysis for diagnostic purposes in the medicine. Tracking cell behaviour during simulation helps to improve the model and adjust its par...

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Bibliographic Details
Main Authors: Slavík Martin, Kovalčíková Kristína, Bachratý Hynek, Bachratá Katarína, Smiešková Monika
Format: Article
Language:English
Published: EDP Sciences 2018-01-01
Series:EPJ Web of Conferences
Online Access:https://doi.org/10.1051/epjconf/201817002092
Description
Summary:Simulations of the red blood cells (RBCs) flow as a movement of elastic objects in a fluid, are developed to optimize microfluidic devices used for a blood sample analysis for diagnostic purposes in the medicine. Tracking cell behaviour during simulation helps to improve the model and adjust its parameters. For the optimization of the microfluidic devices, it is also necessary to analyse cell trajectories as well as likelihood and frequency of their occurrence in a particular device area, especially in the parts, where they can affect circulating tumour cells capture. In this article, we propose and verify several ways of processing and analysing the typology and trajectory stability in simulations with single or with a large number of red blood cells (RBCs) in devices with different topologies containing cylindrical obstacles.
ISSN:2100-014X