PKA at a Cross-Road of Signaling Pathways Involved in the Regulation of Glioblastoma Migration and Invasion by the Neuropeptides VIP and PACAP

PKA at a Cross-Road of Signaling Pathways Involved in the Regulation of Glioblastoma Migration and Invasion by the Neuropeptides VIP and PACAP

Glioblastoma (GBM) remains an incurable disease, mainly due to the high migration and invasion potency of GBM cells inside the brain. PI3K/Akt, Sonic Hedgehog (SHH), and PKA pathways play major regulatory roles in the progression of GBM. The vasoactive intestinal peptide (VIP) family of neuropeptide...

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Bibliographic Details
Main Authors: Souheyla Bensalma, Soumaya Turpault, Annie-Claire Balandre, Madryssa De Boisvilliers, Afsaneh Gaillard, Corinne Chadéneau, Jean-Marc Muller
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cancers
Subjects:
glioblastoma
protein kinase A
Sonic Hedgehog
Akt
PTEN
VIP-receptor system
Online Access:https://www.mdpi.com/2072-6694/11/1/123

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