Intramolecular Azide to Alkene Cycloadditions for the Construction of Pyrrolobenzodiazepines and Azetidino-Benzodiazepines

Intramolecular Azide to Alkene Cycloadditions for the Construction of Pyrrolobenzodiazepines and Azetidino-Benzodiazepines

The coupling of proline- and azetidinone-substituted alkenes to 2-azidobenzoic and 2-azidobenzenesulfonic acid gives precursors that undergo intramolecular azide to alkene 1,3-dipolar cycloadditions to give imine-, triazoline- or aziridine-containing pyrrolo[1,4]benzodiazepines (PBDs), pyrrolo[1,2,5...

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Bibliographic Details
Main Authors: Karl Hemming, Christopher S. Chambers, Faisal Jamshaid, Paul A. O'Gorman
Format: Article
Language:English
Published: MDPI AG 2014-10-01
Series:Molecules
Subjects:
cycloaddition
1,3-dipole
azide
pyrrolobenzodiazepine
azetidinone
antitumour
antibiotic
β-lactam
Online Access:http://www.mdpi.com/1420-3049/19/10/16737

Internet

http://www.mdpi.com/1420-3049/19/10/16737

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