High MAF of EGFR mutations and high ratio of T790M sensitizing mutations in ctDNA predict better third‐generation TKI outcomes

High MAF of EGFR mutations and high ratio of T790M sensitizing mutations in ctDNA predict better third‐generation TKI outcomes

Abstract Background Clinical detection of EGFR‐TKI resistance mechanism through tissue can be really challenging due to risks associated with the procedure. Thus, liquid biopsy, especially circulation tumor DNA (ctDNA) analysis, can be an adequate source for biomarker testing in targeted therapy. Ou...

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Bibliographic Details
Main Authors: Yan Li, Fanshuang Zhang, Pei Yuan, Lei Guo, Ying Jianming, Jie He
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Thoracic Cancer
Subjects:
High‐throughput NGS
liquid biopsy
MAF
outcomes
ratio
Online Access:https://doi.org/10.1111/1759-7714.13418

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