IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development
Immune cells contribute to the aortic wall destruction during abdominal aortic aneurysm (AAA) development. Here, Peshkova et al. show that cytokine signaling through interleukin-27 receptor is required for Angiotensin II-induced myelopoiesis and mature myeloid cells production, thus contributing to...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13017-4 |
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doaj-b6343cfed5b940ac92570f7ff3c8787a2021-05-11T11:41:16ZengNature Publishing GroupNature Communications2041-17232019-11-0110111510.1038/s41467-019-13017-4IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm developmentIuliia O. Peshkova0Turan Aghayev1Aliia R. Fatkhullina2Petr Makhov3Elizaveta K. Titerina4Satoru Eguchi5Yin Fei Tan6Andrew V. Kossenkov7Marina V. Khoreva8Lyudmila V. Gankovskaya9Stephen M. Sykes10Ekaterina K. Koltsova11Blood Cell Development and Function Program, Fox Chase Cancer CenterBlood Cell Development and Function Program, Fox Chase Cancer CenterBlood Cell Development and Function Program, Fox Chase Cancer CenterCancer Biology Program, Fox Chase Cancer CenterBlood Cell Development and Function Program, Fox Chase Cancer CenterLewis Katz School of Medicine, Temple University Cardiovascular Research CenterGenomics Facility, Fox Chase Cancer CenterBioinformatics Facility, The Wistar InstitutePirogov Russian National Research Medical UniversityPirogov Russian National Research Medical UniversityBlood Cell Development and Function Program, Fox Chase Cancer CenterBlood Cell Development and Function Program, Fox Chase Cancer CenterImmune cells contribute to the aortic wall destruction during abdominal aortic aneurysm (AAA) development. Here, Peshkova et al. show that cytokine signaling through interleukin-27 receptor is required for Angiotensin II-induced myelopoiesis and mature myeloid cells production, thus contributing to their aortic accumulation and aneurysm progressionhttps://doi.org/10.1038/s41467-019-13017-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Iuliia O. Peshkova Turan Aghayev Aliia R. Fatkhullina Petr Makhov Elizaveta K. Titerina Satoru Eguchi Yin Fei Tan Andrew V. Kossenkov Marina V. Khoreva Lyudmila V. Gankovskaya Stephen M. Sykes Ekaterina K. Koltsova |
| spellingShingle |
Iuliia O. Peshkova Turan Aghayev Aliia R. Fatkhullina Petr Makhov Elizaveta K. Titerina Satoru Eguchi Yin Fei Tan Andrew V. Kossenkov Marina V. Khoreva Lyudmila V. Gankovskaya Stephen M. Sykes Ekaterina K. Koltsova IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development Nature Communications |
| author_facet |
Iuliia O. Peshkova Turan Aghayev Aliia R. Fatkhullina Petr Makhov Elizaveta K. Titerina Satoru Eguchi Yin Fei Tan Andrew V. Kossenkov Marina V. Khoreva Lyudmila V. Gankovskaya Stephen M. Sykes Ekaterina K. Koltsova |
| author_sort |
Iuliia O. Peshkova |
| title |
IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development |
| title_short |
IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development |
| title_full |
IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development |
| title_fullStr |
IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development |
| title_full_unstemmed |
IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development |
| title_sort |
il-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-11-01 |
| description |
Immune cells contribute to the aortic wall destruction during abdominal aortic aneurysm (AAA) development. Here, Peshkova et al. show that cytokine signaling through interleukin-27 receptor is required for Angiotensin II-induced myelopoiesis and mature myeloid cells production, thus contributing to their aortic accumulation and aneurysm progression |
| url |
https://doi.org/10.1038/s41467-019-13017-4 |
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