An in silico exploration of combining Interleukin-12 with Oxaliplatin to treat liver-metastatic colorectal cancer

An in silico exploration of combining Interleukin-12 with Oxaliplatin to treat liver-metastatic colorectal cancer

Abstract Background Combining anti-cancer therapies with orthogonal modes of action, such as direct cytotoxicity and immunostimulatory, hold promise for expanding clinical benefit to patients with metastatic disease. For instance, a chemotherapy agent Oxaliplatin (OXP) in combination with Interleuki...

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Bibliographic Details
Main Authors: Qing Wang, Zhijun Wang, Yan Wu, David J. Klinke
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Cancer
Subjects:
Adenoviral vector
Combination therapy
Mathematical modeling
Impulsive ordinary differential equation
Stability analysis
Online Access:https://doi.org/10.1186/s12885-019-6500-9

Internet

https://doi.org/10.1186/s12885-019-6500-9

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