An unmethylated 3' promoter-proximal region is required for efficient transcription initiation.

An unmethylated 3' promoter-proximal region is required for efficient transcription initiation.

The promoter regions of approximately 40% of genes in the human genome are embedded in CpG islands, CpG-rich regions that frequently extend on the order of one kb 3' of the transcription start site (TSS) region. CpGs 3' of the TSS of actively transcribed CpG island promoters typically rema...

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Bibliographic Details
Main Authors: Ruth Appanah, David R Dickerson, Preeti Goyal, Mark Groudine, Matthew C Lorincz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC1797817?pdf=render

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