Construction of Hyaluronic Tetrasaccharide Clusters Modified Polyamidoamine siRNA Delivery System

Construction of Hyaluronic Tetrasaccharide Clusters Modified Polyamidoamine siRNA Delivery System

The CD44 protein, as a predominant receptor for hyaluronan (HA), is highly expressed on the surface of multiple tumor cells. HA, as a targeting molecule for a CD44-contained delivery system, increases intracellular drug concentration in tumor tissue. However, due to the weak binding ability of hyalu...

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Bibliographic Details
Main Authors:	Yingcong Ma, Meng Sha, Shixuan Cheng, Wang Yao, Zhongjun Li, Xian-Rong Qi
Format:	Article
Language:	English
Published:	MDPI AG 2018-06-01
Series:	Nanomaterials
Subjects:	hyaluronic acid tetrasaccharide CD44 protein polyamidoamine (PAMAM) dendrimer small interfering RNA cellular uptake endosome escape
Online Access:	http://www.mdpi.com/2079-4991/8/6/433

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