Chlorogenic acid alleviates obesity and modulates gut microbiota in high‐fat‐fed mice

Chlorogenic acid alleviates obesity and modulates gut microbiota in high‐fat‐fed mice

Abstract To evaluate the anti‐obesity effects of chlorogenic acid (CGA), the mice were fed a high‐fat diet (HFD) upon chlorogenic acid treatment for 6 weeks. The results showed administration of chlorogenic acid (150 mg per kg per day) remarkably promoted body loss, reduced lipid levels in plasma an...

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Main Authors: Zhengyu Wang, Ka‐Lung Lam, Jiamiao Hu, Shenghan Ge, Arong Zhou, Baodong Zheng, Shaoxiao Zeng, Shaoling Lin
Format: Article
Language:English
Published: Wiley 2019-02-01
Series:Food Science & Nutrition
Subjects:
body weight
chlorogenic acid
gut microbiota
obesity
Online Access:https://doi.org/10.1002/fsn3.868
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spelling doaj-b61d1f318fdc47b49e980f59dbada8a32020-11-25T00:29:05ZengWileyFood Science & Nutrition2048-71772019-02-017257958810.1002/fsn3.868Chlorogenic acid alleviates obesity and modulates gut microbiota in high‐fat‐fed miceZhengyu Wang0Ka‐Lung Lam1Jiamiao Hu2Shenghan Ge3Arong Zhou4Baodong Zheng5Shaoxiao Zeng6Shaoling Lin7College of Food Science Fujian Agriculture and Forestry University Fuzhou ChinaSchool of Life Sciences The Chinese University of Hong Kong Shatin Hong Kong S.A.R. ChinaCollege of Food Science Fujian Agriculture and Forestry University Fuzhou ChinaCollege of Food Science Fujian Agriculture and Forestry University Fuzhou ChinaCollege of Food Science Fujian Agriculture and Forestry University Fuzhou ChinaCollege of Food Science Fujian Agriculture and Forestry University Fuzhou ChinaCollege of Food Science Fujian Agriculture and Forestry University Fuzhou ChinaCollege of Food Science Fujian Agriculture and Forestry University Fuzhou ChinaAbstract To evaluate the anti‐obesity effects of chlorogenic acid (CGA), the mice were fed a high‐fat diet (HFD) upon chlorogenic acid treatment for 6 weeks. The results showed administration of chlorogenic acid (150 mg per kg per day) remarkably promoted body loss, reduced lipid levels in plasma and altered mRNA expression of lipogenesis and lipolysis related genes in adipose tissue. Moreover, chlorogenic acid also reversed the HFD‐induced gut microbiota dysbiosis, including significantly inhibiting the growth of Desulfovibrionaceae, Ruminococcaceae, Lachnospiraceae, Erysipelotrichaceae, and raising the growth of Bacteroidaceae, Lactobacillaceae. Overall, the amelioration of HFD‐induced gut microbiota dysbiosis by chlorogenic acid may contribute, at least partially, to its beneficial effects on ameliorating HFD‐induced obesity.https://doi.org/10.1002/fsn3.868body weightchlorogenic acidgut microbiotaobesity
collection DOAJ
language English
format Article
sources DOAJ
author Zhengyu Wang
Ka‐Lung Lam
Jiamiao Hu
Shenghan Ge
Arong Zhou
Baodong Zheng
Shaoxiao Zeng
Shaoling Lin
spellingShingle Zhengyu Wang
Ka‐Lung Lam
Jiamiao Hu
Shenghan Ge
Arong Zhou
Baodong Zheng
Shaoxiao Zeng
Shaoling Lin
Chlorogenic acid alleviates obesity and modulates gut microbiota in high‐fat‐fed mice
Food Science & Nutrition
body weight
chlorogenic acid
gut microbiota
obesity
author_facet Zhengyu Wang
Ka‐Lung Lam
Jiamiao Hu
Shenghan Ge
Arong Zhou
Baodong Zheng
Shaoxiao Zeng
Shaoling Lin
author_sort Zhengyu Wang
title Chlorogenic acid alleviates obesity and modulates gut microbiota in high‐fat‐fed mice
title_short Chlorogenic acid alleviates obesity and modulates gut microbiota in high‐fat‐fed mice
title_full Chlorogenic acid alleviates obesity and modulates gut microbiota in high‐fat‐fed mice
title_fullStr Chlorogenic acid alleviates obesity and modulates gut microbiota in high‐fat‐fed mice
title_full_unstemmed Chlorogenic acid alleviates obesity and modulates gut microbiota in high‐fat‐fed mice
title_sort chlorogenic acid alleviates obesity and modulates gut microbiota in high‐fat‐fed mice
publisher Wiley
series Food Science & Nutrition
issn 2048-7177
publishDate 2019-02-01
description Abstract To evaluate the anti‐obesity effects of chlorogenic acid (CGA), the mice were fed a high‐fat diet (HFD) upon chlorogenic acid treatment for 6 weeks. The results showed administration of chlorogenic acid (150 mg per kg per day) remarkably promoted body loss, reduced lipid levels in plasma and altered mRNA expression of lipogenesis and lipolysis related genes in adipose tissue. Moreover, chlorogenic acid also reversed the HFD‐induced gut microbiota dysbiosis, including significantly inhibiting the growth of Desulfovibrionaceae, Ruminococcaceae, Lachnospiraceae, Erysipelotrichaceae, and raising the growth of Bacteroidaceae, Lactobacillaceae. Overall, the amelioration of HFD‐induced gut microbiota dysbiosis by chlorogenic acid may contribute, at least partially, to its beneficial effects on ameliorating HFD‐induced obesity.
topic body weight
chlorogenic acid
gut microbiota
obesity
url https://doi.org/10.1002/fsn3.868
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