Total Synthesis and Antimicrobial Evaluation of 23-Demethyleushearilide and Extensive Antimicrobial Evaluation of All Synthetic Stereoisomers of (16<i>Z</i>,20<i>E</i>)-Eushearilide and (16<i>E</i>,20<i>E</i>)-Eushearilide

Total Synthesis and Antimicrobial Evaluation of 23-Demethyleushearilide and Extensive Antimicrobial Evaluation of All Synthetic Stereoisomers of (16<i>Z</i>,20<i>E</i>)-Eushearilide and (16<i>E</i>,20<i>E</i>)-Eushearilide

A novel stereoisomer of eushearilide, 23-demethyleushearilide, was synthesized, and the structure&#8722;activity relationships of this compound along with known eushearilide stereoisomers were investigated in order to design novel lead compounds for the treatment of fungal infections. It was dis...

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Bibliographic Details
Main Authors: Takayuki Tonoi, Takehiko Inohana, Teruyuki Sato, Yuuki Noda, Miyuki Ikeda, Miku Akutsu, Takatsugu Murata, Yutaro Maekawa, Anna Tanaka, Rio Seki, Misako Ohkusu, Katsuhiko Kamei, Naruhiko Ishiwada, Isamu Shiina
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Molecules
Subjects:
eushearilide
demethyl congener
total synthesis
lactonization
MNBA
antimicrobial activity
Online Access:https://www.mdpi.com/1420-3049/24/19/3437

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