The Effect of Fluid Shear Stress on the In Vitro Release Kinetics of Sirolimus from PLGA Films

The Effect of Fluid Shear Stress on the In Vitro Release Kinetics of Sirolimus from PLGA Films

Drug-carrying coatings of stents implanted in blood vessels are exposed to various blood flows. This study investigated the effect of fluid shear stress on the in vitro release kinetics of sirolimus from poly(lactic-co-glycolic acid) (PLGA) films. The homemade parallel plate flow chamber was used to...

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Bibliographic Details
Main Authors: Quan Zheng, Zhaowei Chu, Xiaoming Li, Hongyan Kang, Xiao Yang, Yubo Fan
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Polymers
Subjects:
sirolimus release
PLGA degradation
uniform shear stress
parallel plate flow chamber
drug-eluting stent
biodegradable coating
hemodynamics
Online Access:https://www.mdpi.com/2073-4360/9/11/618

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