Splicing Regulators and Their Roles in Cancer Biology and Therapy

Alternative splicing allows cells to expand the encoding potential of their genomes. In this elegant mechanism, a single gene can yield protein isoforms with even antagonistic functions depending on the cellular physiological context. Alterations in splicing regulatory factors activity in cancer cel...

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Main Authors:	Maria Roméria da Silva, Gabriela Alves Moreira, Ronni Anderson Gonçalves da Silva, Éverton de Almeida Alves Barbosa, Raoni Pais Siqueira, Róbson Ricardo Teixera, Márcia Rogéria Almeida, Abelardo Silva Júnior, Juliana Lopes Rangel Fietto, Gustavo Costa Bressan
Format:	Article
Language:	English
Published:	Hindawi Limited 2015-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2015/150514

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spelling	doaj-b603a592ca494330ba2819695fac985a2020-11-24T22:47:15ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/150514150514Splicing Regulators and Their Roles in Cancer Biology and TherapyMaria Roméria da Silva0Gabriela Alves Moreira1Ronni Anderson Gonçalves da Silva2Éverton de Almeida Alves Barbosa3Raoni Pais Siqueira4Róbson Ricardo Teixera5Márcia Rogéria Almeida6Abelardo Silva Júnior7Juliana Lopes Rangel Fietto8Gustavo Costa Bressan9Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, BrazilDepartamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, BrazilDepartamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, BrazilDepartamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, BrazilDepartamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, BrazilDepartamento de Química, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, BrazilDepartamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, BrazilDepartamento de Veterinária, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, BrazilDepartamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, BrazilDepartamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, BrazilAlternative splicing allows cells to expand the encoding potential of their genomes. In this elegant mechanism, a single gene can yield protein isoforms with even antagonistic functions depending on the cellular physiological context. Alterations in splicing regulatory factors activity in cancer cells, however, can generate an abnormal protein expression pattern that promotes growth, survival, and other processes, which are relevant to tumor biology. In this review, we discuss dysregulated alternative splicing events and regulatory factors that impact pathways related to cancer. The SR proteins and their regulatory kinases SRPKs and CLKs have been frequently found altered in tumors and are examined in more detail. Finally, perspectives that support splicing machinery as target for the development of novel anticancer therapies are discussed.http://dx.doi.org/10.1155/2015/150514
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Maria Roméria da Silva Gabriela Alves Moreira Ronni Anderson Gonçalves da Silva Éverton de Almeida Alves Barbosa Raoni Pais Siqueira Róbson Ricardo Teixera Márcia Rogéria Almeida Abelardo Silva Júnior Juliana Lopes Rangel Fietto Gustavo Costa Bressan
spellingShingle	Maria Roméria da Silva Gabriela Alves Moreira Ronni Anderson Gonçalves da Silva Éverton de Almeida Alves Barbosa Raoni Pais Siqueira Róbson Ricardo Teixera Márcia Rogéria Almeida Abelardo Silva Júnior Juliana Lopes Rangel Fietto Gustavo Costa Bressan Splicing Regulators and Their Roles in Cancer Biology and Therapy BioMed Research International
author_facet	Maria Roméria da Silva Gabriela Alves Moreira Ronni Anderson Gonçalves da Silva Éverton de Almeida Alves Barbosa Raoni Pais Siqueira Róbson Ricardo Teixera Márcia Rogéria Almeida Abelardo Silva Júnior Juliana Lopes Rangel Fietto Gustavo Costa Bressan
author_sort	Maria Roméria da Silva
title	Splicing Regulators and Their Roles in Cancer Biology and Therapy
title_short	Splicing Regulators and Their Roles in Cancer Biology and Therapy
title_full	Splicing Regulators and Their Roles in Cancer Biology and Therapy
title_fullStr	Splicing Regulators and Their Roles in Cancer Biology and Therapy
title_full_unstemmed	Splicing Regulators and Their Roles in Cancer Biology and Therapy
title_sort	splicing regulators and their roles in cancer biology and therapy
publisher	Hindawi Limited
series	BioMed Research International
issn	2314-6133 2314-6141
publishDate	2015-01-01
description	Alternative splicing allows cells to expand the encoding potential of their genomes. In this elegant mechanism, a single gene can yield protein isoforms with even antagonistic functions depending on the cellular physiological context. Alterations in splicing regulatory factors activity in cancer cells, however, can generate an abnormal protein expression pattern that promotes growth, survival, and other processes, which are relevant to tumor biology. In this review, we discuss dysregulated alternative splicing events and regulatory factors that impact pathways related to cancer. The SR proteins and their regulatory kinases SRPKs and CLKs have been frequently found altered in tumors and are examined in more detail. Finally, perspectives that support splicing machinery as target for the development of novel anticancer therapies are discussed.
url	http://dx.doi.org/10.1155/2015/150514
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Splicing Regulators and Their Roles in Cancer Biology and Therapy

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