Conjunctival squamous cell carcinoma: outcome analysis of 55 cases in Abidjan

AIM: To determine epidemiological, clinical profile and access the impact of HIV in its occurrence in 55 eyes of conjunctival squamous cell carcinoma.<p>METHODS: A cross sectional study, 55 eyes of 54 patients affected by conjunctival squamous cell carcinoma(CSCs)presented in the Ophthalmology...

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Main Authors: Rokia Coulibaly Berete, Thierry Yves Constant Sowagnon, Abokan Joel Konan, Sylvanius Beossin Koui, Sandrine Kouassi Kouakou, Simon N'Dri Dede, Adama Fanny
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2017-12-01
Series:Guoji Yanke Zazhi
Subjects:
Online Access:http://ies.ijo.cn/cn_publish/2017/12/201712001.pdf
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spelling doaj-b5f346c10a53418f9e471f9d9d6cbe1c2020-11-24T23:33:07ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232017-12-0117122187219210.3980/j.issn.1672-5123.2017.12.01Conjunctival squamous cell carcinoma: outcome analysis of 55 cases in AbidjanRokia Coulibaly Berete0Thierry Yves Constant Sowagnon1Abokan Joel Konan2Sylvanius Beossin Koui3Sandrine Kouassi Kouakou4Simon N'Dri Dede5Adama Fanny6Department of Ophthalmology, the Teaching Hospital of Treichville, 01 BP V3 Abidjan 01, Ivory CoastDepartment of Ophthalmology, the Teaching Hospital of Yopougon, 21 BP 632 Abidjan 21, Ivory CoastDepartment of Ophthalmology, the Teaching Hospital of Treichville, 01 BP V3 Abidjan 01, Ivory CoastDepartment of Pathology, Teaching Hospital of Treichville, 01 BP V3 Abidjan 01, Ivory CoastDepartment of Ophthalmology, the Teaching Hospital of Treichville, 01 BP V3 Abidjan 01, Ivory CoastDepartment of Imaging, Teaching Hospital of Treichville, 01 BP V3 Abidjan 01, Ivory CoastDepartment of Ophthalmology, the Teaching Hospital of Treichville, 01 BP V3 Abidjan 01, Ivory CoastAIM: To determine epidemiological, clinical profile and access the impact of HIV in its occurrence in 55 eyes of conjunctival squamous cell carcinoma.<p>METHODS: A cross sectional study, 55 eyes of 54 patients affected by conjunctival squamous cell carcinoma(CSCs)presented in the Ophthalmology Department of University Hospital of Treichville in Abidjan were included. Data were collected: interrogatories, ophthalmologic examination, histopathologic finding, HIV serology, therapeutic(surgery, chemotherapy), follow-up and prognosis. The statistical analysis was performed using Epi-info version 6.0 and a statistical comparison was performed using the Chi-square test with a significance threshold set at 5%.<p>RESULTS: The age ranged 7-75y(median age 42.28). A female predominance was observed with a sex-ratio of 0.89. The average consultation period was 18mo, with extremes ranging from 6-60mo. Physically 53% of our eyes(29 eyes)presented a functional loss of the eye. And 42 out of the 54 patients were HIV positive with 28 cases of HIV1 infection, 4 cases of HIV2 infection and 10 cases of HIV1 and 2 co-infection. Lymphocyte typing was performed for 28 out of 42 patients with CD4 cell counts <200/mL in 33% of cases, between 200 and 500 in 19% of cases and 500/mL in 12% of cases. It was noted 42 cases(76%)of invasive differentiated squamous cell carcinoma, and 13 cases(24%)of squamous cell carcinoma <i>in situ</i>. Forty localized tumors underwent tumor resection(73%)associated with a postoperative adjuvant topical chemotherapy in 6 cases. Socioeconomic status showed 39% of patients were economic cally inactive. The average follow up period of our patients was 29mo. <p>CONCLUSION: HIV infection is a risk factor for the occurrence of conjunctival squamous cell carcinoma especially in sub-Saharan Africa where the fight against the infection although boosted in these recent years is far from achieving all objectives. The poor prognosis of conjunctival squamous cell carcinoma reflects the low socioeconomic status of patients, the inadequate medical care in our facilities, the prohibitive cost of anticancer drugs and the link between this disease and HIV/AIDS.http://ies.ijo.cn/cn_publish/2017/12/201712001.pdfcarcinoma; squamous cell; acquired human immunodeficiencycarcinomasquamous cellacquired human immunodeficiency
collection DOAJ
language English
format Article
sources DOAJ
author Rokia Coulibaly Berete
Thierry Yves Constant Sowagnon
Abokan Joel Konan
Sylvanius Beossin Koui
Sandrine Kouassi Kouakou
Simon N'Dri Dede
Adama Fanny
spellingShingle Rokia Coulibaly Berete
Thierry Yves Constant Sowagnon
Abokan Joel Konan
Sylvanius Beossin Koui
Sandrine Kouassi Kouakou
Simon N'Dri Dede
Adama Fanny
Conjunctival squamous cell carcinoma: outcome analysis of 55 cases in Abidjan
Guoji Yanke Zazhi
carcinoma; squamous cell; acquired human immunodeficiency
carcinoma
squamous cell
acquired human immunodeficiency
author_facet Rokia Coulibaly Berete
Thierry Yves Constant Sowagnon
Abokan Joel Konan
Sylvanius Beossin Koui
Sandrine Kouassi Kouakou
Simon N'Dri Dede
Adama Fanny
author_sort Rokia Coulibaly Berete
title Conjunctival squamous cell carcinoma: outcome analysis of 55 cases in Abidjan
title_short Conjunctival squamous cell carcinoma: outcome analysis of 55 cases in Abidjan
title_full Conjunctival squamous cell carcinoma: outcome analysis of 55 cases in Abidjan
title_fullStr Conjunctival squamous cell carcinoma: outcome analysis of 55 cases in Abidjan
title_full_unstemmed Conjunctival squamous cell carcinoma: outcome analysis of 55 cases in Abidjan
title_sort conjunctival squamous cell carcinoma: outcome analysis of 55 cases in abidjan
publisher Press of International Journal of Ophthalmology (IJO PRESS)
series Guoji Yanke Zazhi
issn 1672-5123
1672-5123
publishDate 2017-12-01
description AIM: To determine epidemiological, clinical profile and access the impact of HIV in its occurrence in 55 eyes of conjunctival squamous cell carcinoma.<p>METHODS: A cross sectional study, 55 eyes of 54 patients affected by conjunctival squamous cell carcinoma(CSCs)presented in the Ophthalmology Department of University Hospital of Treichville in Abidjan were included. Data were collected: interrogatories, ophthalmologic examination, histopathologic finding, HIV serology, therapeutic(surgery, chemotherapy), follow-up and prognosis. The statistical analysis was performed using Epi-info version 6.0 and a statistical comparison was performed using the Chi-square test with a significance threshold set at 5%.<p>RESULTS: The age ranged 7-75y(median age 42.28). A female predominance was observed with a sex-ratio of 0.89. The average consultation period was 18mo, with extremes ranging from 6-60mo. Physically 53% of our eyes(29 eyes)presented a functional loss of the eye. And 42 out of the 54 patients were HIV positive with 28 cases of HIV1 infection, 4 cases of HIV2 infection and 10 cases of HIV1 and 2 co-infection. Lymphocyte typing was performed for 28 out of 42 patients with CD4 cell counts <200/mL in 33% of cases, between 200 and 500 in 19% of cases and 500/mL in 12% of cases. It was noted 42 cases(76%)of invasive differentiated squamous cell carcinoma, and 13 cases(24%)of squamous cell carcinoma <i>in situ</i>. Forty localized tumors underwent tumor resection(73%)associated with a postoperative adjuvant topical chemotherapy in 6 cases. Socioeconomic status showed 39% of patients were economic cally inactive. The average follow up period of our patients was 29mo. <p>CONCLUSION: HIV infection is a risk factor for the occurrence of conjunctival squamous cell carcinoma especially in sub-Saharan Africa where the fight against the infection although boosted in these recent years is far from achieving all objectives. The poor prognosis of conjunctival squamous cell carcinoma reflects the low socioeconomic status of patients, the inadequate medical care in our facilities, the prohibitive cost of anticancer drugs and the link between this disease and HIV/AIDS.
topic carcinoma; squamous cell; acquired human immunodeficiency
carcinoma
squamous cell
acquired human immunodeficiency
url http://ies.ijo.cn/cn_publish/2017/12/201712001.pdf
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