Intratracheal synthetic CpG oligodeoxynucleotide causes acute lung injury with systemic inflammatory response

Intratracheal synthetic CpG oligodeoxynucleotide causes acute lung injury with systemic inflammatory response

<p>Abstract</p> <p>Bacterial genome is characterized by frequent unmethylated cytosine-phosphate-guanine (CpG) motifs. Deleterious effects can occur when synthetic oligodeoxynucleotides (ODN) with unmethylated CpG dinucleotides (CpG-ODN) are administered in a systemic fashion. We a...

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Main Authors: Hasegawa Naoki, Fujiwara Hiroshi, Kimizuka Yoshifumi, Shinoda Hiromi, Nakano Yasushi, Miyamoto Keisuke, Kamata Hirofumi, Tasaka Sadatomo, Fujishima Seitaro, Miyasho Taku, Ishizaka Akitoshi
Format: Article
Language:English
Published: BMC 2009-09-01
Series:Respiratory Research
Online Access:http://respiratory-research.com/content/10/1/84

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http://respiratory-research.com/content/10/1/84

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