Organelle acidification: an ancient cellular leak detector
Abstract Intracellular membrane-bounded organelles of eukaryotic cells transiently contact the extracellular environment during endocytosis and secretion. Such contacts must be precisely timed to prevent leakage of cargo. I argue that early eukaryotes evolved organelle acidification as a way to dete...
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| Format: | Article |
| Language: | English |
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BMC
2017-06-01
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| Series: | BMC Biology |
| Online Access: | http://link.springer.com/article/10.1186/s12915-017-0395-1 |