Organelle acidification: an ancient cellular leak detector
Abstract Intracellular membrane-bounded organelles of eukaryotic cells transiently contact the extracellular environment during endocytosis and secretion. Such contacts must be precisely timed to prevent leakage of cargo. I argue that early eukaryotes evolved organelle acidification as a way to dete...
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2017-06-01
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| Series: | BMC Biology |
| Online Access: | http://link.springer.com/article/10.1186/s12915-017-0395-1 |
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doaj-b5e16a5f2fef49ef9caa67c20cb57ac92020-11-25T02:20:28ZengBMCBMC Biology1741-70072017-06-011511410.1186/s12915-017-0395-1Organelle acidification: an ancient cellular leak detectorMukund Thattai0Simons Centre for the Study of Living Machines, National Centre for Biological Sciences, Tata Institute of Fundamental Research, GKVK CampusAbstract Intracellular membrane-bounded organelles of eukaryotic cells transiently contact the extracellular environment during endocytosis and secretion. Such contacts must be precisely timed to prevent leakage of cargo. I argue that early eukaryotes evolved organelle acidification as a way to detect and prevent leakage.http://link.springer.com/article/10.1186/s12915-017-0395-1 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Mukund Thattai |
| spellingShingle |
Mukund Thattai Organelle acidification: an ancient cellular leak detector BMC Biology |
| author_facet |
Mukund Thattai |
| author_sort |
Mukund Thattai |
| title |
Organelle acidification: an ancient cellular leak detector |
| title_short |
Organelle acidification: an ancient cellular leak detector |
| title_full |
Organelle acidification: an ancient cellular leak detector |
| title_fullStr |
Organelle acidification: an ancient cellular leak detector |
| title_full_unstemmed |
Organelle acidification: an ancient cellular leak detector |
| title_sort |
organelle acidification: an ancient cellular leak detector |
| publisher |
BMC |
| series |
BMC Biology |
| issn |
1741-7007 |
| publishDate |
2017-06-01 |
| description |
Abstract Intracellular membrane-bounded organelles of eukaryotic cells transiently contact the extracellular environment during endocytosis and secretion. Such contacts must be precisely timed to prevent leakage of cargo. I argue that early eukaryotes evolved organelle acidification as a way to detect and prevent leakage. |
| url |
http://link.springer.com/article/10.1186/s12915-017-0395-1 |
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AT mukundthattai organelleacidificationanancientcellularleakdetector |
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