SLE and Tuberculosis: A Case Series and Review of Literature
Systemic Lupus Erythematosus (SLE) and Tuberculosis (TB) are intricately related with an increase in the risk of TB in SLE. Primary mechanisms pertaining to the increased susceptibility for TB are the inherent immunodeficient state of SLE and use of immunosuppressant agents in the treatment of SLE...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/9398/22749_CE(EK)_F(RK)_PF1(PI_RK)_PFA(AK)_PF2(P_PC)_PF3(AG_OM).pdf |
| Summary: | Systemic Lupus Erythematosus (SLE) and Tuberculosis (TB) are intricately related with an increase in the risk of TB in SLE. Primary
mechanisms pertaining to the increased susceptibility for TB are the inherent immunodeficient state of SLE and use of immunosuppressant
agents in the treatment of SLE. We report a case series of five female patients of SLE with TB who presented between January 2015
and December 2015 in a tertiary care teaching hospital in North Eastern India. All the patients were young to middle aged females
having SLE with or without lupus nephritis who were on immunosuppressive therapy with corticosteroids, mycophenolate mofetil or
cyclophosphamide. Two of the cases had sputum positive pulmonary tuberculosis while rest had Extra-Pulmonary TB (EPTB). The
response to anti-tubercular therapy led to clinical improvement in all the cases except one who had an adverse outcome. Our series
further substantiates the increased risk of TB in SLE thus, prompting further research towards better management of these two disease
entities in conjunction. |
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| ISSN: | 2249-782X 0973-709X |