Classical and paradoxical effects of TNF-α on bone homeostasis

Classical and paradoxical effects of TNF-α on bone homeostasis

TNF-α plays an essential role in the regulation of bone homeostasis in several chronic immune and inflammatory joint diseases, where inhibition of TNF has led to significant clinical improvement. However, TNF-activated pathways and mechanisms involved in bone remodeling remain unclear. So far, TNF-α...

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Bibliographic Details
Main Authors: Bilal eOsta, Giulia eBenedetti, Pierre eMiossec
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Immunology
Subjects:
Osteoporosis
Rheumatoid arthritis
osteoblast
osteoclast
ankylosing spondylitis
TNF-
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00048/full

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