RAD52 Adjusts Repair of Single-Strand Breaks via Reducing DNA-Damage-Promoted XRCC1/LIG3α Co-localization

RAD52 Adjusts Repair of Single-Strand Breaks via Reducing DNA-Damage-Promoted XRCC1/LIG3α Co-localization

Summary: Radiation sensitive 52 (RAD52) is an important factor for double-strand break repair (DSBR). However, deficiency in vertebrate/mammalian Rad52 has no apparent phenotype. The underlying mechanism remains elusive. Here, we report that RAD52 deficiency increased cell survival after camptotheci...

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Bibliographic Details
Main Authors: Jian Wang, You-Take Oh, Zhentian Li, Juan Dou, Siyuan Tang, Xiang Wang, Hongyan Wang, Shunichi Takeda, Ya Wang
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cell Reports
Subjects:
RAD52
XRCC1
DNA damage
single-strand breaks
DNA repair
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720316144

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http://www.sciencedirect.com/science/article/pii/S2211124720316144

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