A prosaposin-derived Peptide alleviates kainic Acid-induced brain injury.

A prosaposin-derived Peptide alleviates kainic Acid-induced brain injury.

Four sphingolipid activator proteins (i.e., saposins A-D) are synthesized from a single precursor protein, prosaposin (PS), which exerts exogenous neurotrophic effects in vivo and in vitro. Kainic acid (KA) injection in rodents is a good model in which to study neurotrophic factor elevation; PS and...

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Bibliographic Details
Main Authors: Hiroaki Nabeka, Tetsuya Shimokawa, Takuya Doihara, Shouichiro Saito, Hiroyuki Wakisaka, Fumihiko Hamada, Naoto Kobayashi, Seiji Matsuda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4436272?pdf=render

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http://europepmc.org/articles/PMC4436272?pdf=render

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