Eltrombopag modulates reactive oxygen species and decreases acute myeloid leukemia cell survival.

Eltrombopag modulates reactive oxygen species and decreases acute myeloid leukemia cell survival.

Previous studies have demonstrated that the small molecule thrombopoietin (TPO) mimetic, eltrombopag (E), induces apoptosis in acute myeloid leukemia (AML) cells. Here, we sought to define the mechanism of the anti-leukemic effect of eltrombopag. Our studies demonstrate that, at a concentration of 5...

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Bibliographic Details
Main Authors: Anna Kalota, Mary A Selak, Laura A Garcia-Cid, Martin Carroll
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4411049?pdf=render

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