Shorter TCR β-Chains Are Highly Enriched During Thymic Selection and Antigen-Driven Selection

Shorter TCR β-Chains Are Highly Enriched During Thymic Selection and Antigen-Driven Selection

The adaptive immune system uses several strategies to generate a repertoire of T cell receptors (TCR) with sufficient diversity to recognize the universe of potential pathogens. However, it remains unclear how differences in the T cell receptor (TCR) contribute to heterogeneity in T cell state. In t...

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Bibliographic Details
Main Authors: Xianliang Hou, Ping Zeng, Xujun Zhang, Jianing Chen, Yan Liang, Jiezuan Yang, Yida Yang, Xiangdong Liu, Hongyan Diao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
T cell receptor
cell subsets
deep sequencing
memory T cell
naive T cell
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00299/full

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