Fibronectin aggregates promote features of a classically and alternatively activated phenotype in macrophages

Fibronectin aggregates promote features of a classically and alternatively activated phenotype in macrophages

Abstract Background Means to promote endogenous remyelination in multiple sclerosis (MS) benefit from insights into the role of inhibitory molecules that preclude remyelination. Fibronectin assembles into aggregates in MS, which impair oligodendrocyte differentiation and remyelination. Microglia and...

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Bibliographic Details
Main Authors: Arend H. Sikkema, Josephine M. J. Stoffels, Peng Wang, Frederike J. Basedow, Robbert Bulsink, Jeffrey J. Bajramovic, Wia Baron
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Neuroinflammation
Subjects:
Fibronectin
Macrophage
Microglia
Multiple sclerosis
Online Access:http://link.springer.com/article/10.1186/s12974-018-1238-x

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