Super-charged NK cells inhibit growth and progression of stem-like/poorly differentiated oral tumors in vivo in humanized BLT mice; effect on tumor differentiation and response to chemotherapeutic drugs

Super-charged NK cells inhibit growth and progression of stem-like/poorly differentiated oral tumors in vivo in humanized BLT mice; effect on tumor differentiation and response to chemotherapeutic drugs

Therapeutic role of NK cells in solid tumors was challenged previously even though their role in hematological malignancies has clearly been established. Furthermore, functions and numbers of NK cells are greatly suppressed in oral cancer patients necessitating effective future NK immunotherapeutic...

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Bibliographic Details
Main Authors: Kawaljit Kaur, Paytsar Topchyan, Anna Karolina Kozlowska, Nick Ohanian, Jessica Chiang, Phyu Ou Maung, So-Hyun Park, Meng-Wei Ko, Changge Fang, Ichiro Nishimura, Anahid Jewett
Format: Article
Language:English
Published: Taylor & Francis Group 2018-05-01
Series:OncoImmunology
Subjects:
differentiation
blt-nsg
ifn-γ
nk
oscscs
osccs
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1426518

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