Acute treatment with valproic acid and l-thyroxine ameliorates clinical signs of experimental autoimmune encephalomyelitis and prevents brain pathology in DA rats

Acute treatment with valproic acid and l-thyroxine ameliorates clinical signs of experimental autoimmune encephalomyelitis and prevents brain pathology in DA rats

Multiple sclerosis (MS) is the most common chronic inflammatory demyelinating disease of the central nervous system (CNS) in young adults. Chronic treatments with histone deacetylase inhibitors (HDACis) have been reported to ameliorate experimental autoimmune encephalomyelitis (EAE), a rodent model...

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Bibliographic Details
Main Authors: Gonçalo Castelo-Branco, Pernilla Stridh, André Ortlieb Guerreiro-Cacais, Milena Z. Adzemovic, Ana Mendanha Falcão, Monica Marta, Rasmus Berglund, Alan Gillett, Kedir Hussen Hamza, Hans Lassmann, Ola Hermanson, Maja Jagodic
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Neurobiology of Disease
Subjects:
Multiple sclerosis
Experimental autoimmune encephalomyelitis
Epigenetics
Histone deacetylases
Thyroid hormone
Neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114002502

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http://www.sciencedirect.com/science/article/pii/S0969996114002502

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