Effectiveness in the Block by Honokiol, a Dimerized Allylphenol from<i> Magnolia Officinalis</i>, of Hyperpolarization-Activated Cation Current and Delayed-Rectifier K<sup>+</sup> Current

Effectiveness in the Block by Honokiol, a Dimerized Allylphenol from<i> Magnolia Officinalis</i>, of Hyperpolarization-Activated Cation Current and Delayed-Rectifier K<sup>+</sup> Current

<strong>Background:</strong> Honokiol (HNK), a dimer of allylphenol obtained from the bark of <em>Magnolia officinalis</em> was demonstrated to exert an array of biological actions in different excitable cell types. However, whether or how this compound can lead to any pertur...

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Main Authors: Ming-Huan Chan, Hwei-Hsien Chen, Yi-Ching Lo, Sheng-Nan Wu
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
honokiol
hyperpolarization-activated cation current
current kinetics
pituitary cell
olfactory neuron
Online Access:https://www.mdpi.com/1422-0067/21/12/4260
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spelling doaj-b58aa02e9bd9422a839f24b1c72a79602020-11-25T02:30:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-06-01214260426010.3390/ijms21124260Effectiveness in the Block by Honokiol, a Dimerized Allylphenol from<i> Magnolia Officinalis</i>, of Hyperpolarization-Activated Cation Current and Delayed-Rectifier K<sup>+</sup> CurrentMing-Huan Chan0Hwei-Hsien Chen1Yi-Ching Lo2Sheng-Nan Wu3Institute of Neuroscience, National Chengchi University, Taipei 11605, TaiwanInstitute of Neuroscience, National Chengchi University, Taipei 11605, TaiwanDepartment of Pharmacology, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDepartment of Physiology, National Cheng Kung University Medical College, Tainan 70101, Taiwan<strong>Background:</strong> Honokiol (HNK), a dimer of allylphenol obtained from the bark of <em>Magnolia officinalis</em> was demonstrated to exert an array of biological actions in different excitable cell types. However, whether or how this compound can lead to any perturbations on surface–membrane ionic currents remains largely unknown[...]https://www.mdpi.com/1422-0067/21/12/4260honokiolhyperpolarization-activated cation currentcurrent kineticspituitary cellolfactory neuron
collection DOAJ
language English
format Article
sources DOAJ
author Ming-Huan Chan
Hwei-Hsien Chen
Yi-Ching Lo
Sheng-Nan Wu
spellingShingle Ming-Huan Chan
Hwei-Hsien Chen
Yi-Ching Lo
Sheng-Nan Wu
Effectiveness in the Block by Honokiol, a Dimerized Allylphenol from<i> Magnolia Officinalis</i>, of Hyperpolarization-Activated Cation Current and Delayed-Rectifier K<sup>+</sup> Current
International Journal of Molecular Sciences
honokiol
hyperpolarization-activated cation current
current kinetics
pituitary cell
olfactory neuron
author_facet Ming-Huan Chan
Hwei-Hsien Chen
Yi-Ching Lo
Sheng-Nan Wu
author_sort Ming-Huan Chan
title Effectiveness in the Block by Honokiol, a Dimerized Allylphenol from<i> Magnolia Officinalis</i>, of Hyperpolarization-Activated Cation Current and Delayed-Rectifier K<sup>+</sup> Current
title_short Effectiveness in the Block by Honokiol, a Dimerized Allylphenol from<i> Magnolia Officinalis</i>, of Hyperpolarization-Activated Cation Current and Delayed-Rectifier K<sup>+</sup> Current
title_full Effectiveness in the Block by Honokiol, a Dimerized Allylphenol from<i> Magnolia Officinalis</i>, of Hyperpolarization-Activated Cation Current and Delayed-Rectifier K<sup>+</sup> Current
title_fullStr Effectiveness in the Block by Honokiol, a Dimerized Allylphenol from<i> Magnolia Officinalis</i>, of Hyperpolarization-Activated Cation Current and Delayed-Rectifier K<sup>+</sup> Current
title_full_unstemmed Effectiveness in the Block by Honokiol, a Dimerized Allylphenol from<i> Magnolia Officinalis</i>, of Hyperpolarization-Activated Cation Current and Delayed-Rectifier K<sup>+</sup> Current
title_sort effectiveness in the block by honokiol, a dimerized allylphenol from<i> magnolia officinalis</i>, of hyperpolarization-activated cation current and delayed-rectifier k<sup>+</sup> current
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2020-06-01
description <strong>Background:</strong> Honokiol (HNK), a dimer of allylphenol obtained from the bark of <em>Magnolia officinalis</em> was demonstrated to exert an array of biological actions in different excitable cell types. However, whether or how this compound can lead to any perturbations on surface–membrane ionic currents remains largely unknown[...]
topic honokiol
hyperpolarization-activated cation current
current kinetics
pituitary cell
olfactory neuron
url https://www.mdpi.com/1422-0067/21/12/4260
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AT yichinglo effectivenessintheblockbyhonokioladimerizedallylphenolfromimagnoliaofficinalisiofhyperpolarizationactivatedcationcurrentanddelayedrectifierksupsupcurrent
AT shengnanwu effectivenessintheblockbyhonokioladimerizedallylphenolfromimagnoliaofficinalisiofhyperpolarizationactivatedcationcurrentanddelayedrectifierksupsupcurrent
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