Insight into the Structural Determinants of Imidazole Scaffold-Based Derivatives as TNF-α Release Inhibitors by in Silico Explorations

Insight into the Structural Determinants of Imidazole Scaffold-Based Derivatives as TNF-α Release Inhibitors by in Silico Explorations

Presently, 151 widely-diverse pyridinylimidazole-based compounds that show inhibitory activities at the TNF-α release were investigated. By using the distance comparison technique (DISCOtech), comparative molecular field analysis (CoMFA), and comparative molecular similarity index analysis (CoMSIA)...

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Bibliographic Details
Main Authors: Yuan Wang, Mingwei Wu, Chunzhi Ai, Yonghua Wang
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:International Journal of Molecular Sciences
Subjects:
imidazoles
TNF-α
inhibitor
3D-QSAR
CoMFA
CoMSIA
DISCOtech
pharmacophore
Online Access:http://www.mdpi.com/1422-0067/16/9/20118

Internet

http://www.mdpi.com/1422-0067/16/9/20118

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