Celastrol Alleviates Aortic Valve Calcification Via Inhibition of NADPH Oxidase 2 in Valvular Interstitial Cells

Celastrol Alleviates Aortic Valve Calcification Via Inhibition of NADPH Oxidase 2 in Valvular Interstitial Cells

Summary: This study sought to investigate whether reactive oxygen species (ROS)–generating reduced nicotinamide adenine dinucleotide phosphate oxidase 2 (Nox2) contributes to calcific aortic valve disease (CAVD) or whether celastrol, a natural Nox2 inhibitor, may provide potential therapeutic target...

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Main Authors: Huibing Liu, MS, Libo Wang, MS, Yating Pan, MD, Xuehui Wang, MD, PhD, Yuan Ding, BSM, Chaoyuan Zhou, MD, Ajay M. Shah, MD, Guoan Zhao, MD, PhD, Min Zhang, MD, PhD
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X19303079

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http://www.sciencedirect.com/science/article/pii/S2452302X19303079

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