Comparison of metal-dependent catalysis by HIV-1 and ASV integrase proteins using a new and rapid, moderate throughput assay for joining activity in solution

Comparison of metal-dependent catalysis by HIV-1 and ASV integrase proteins using a new and rapid, moderate throughput assay for joining activity in solution

<p>Abstract</p> <p>Background</p> <p>HIV-1 integrase (IN) is an attractive target for the development of drugs to treat AIDS, and inhibitors of this viral enzyme are already in the clinic. Nevertheless, there is a continuing need to devise new approaches to block the ac...

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Bibliographic Details
Main Authors: Burke Terrence R, Zhao Xue, Merkel George, Ramcharan Joseph, Andrake Mark D, Skalka Anna
Format: Article
Language:English
Published: BMC 2009-06-01
Series:AIDS Research and Therapy
Online Access:http://www.aidsrestherapy.com/content/6/1/14

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