Serpin treatment suppresses inflammatory vascular lesions in temporal artery implants (TAI) from patients with giant cell arteritis.

Serpin treatment suppresses inflammatory vascular lesions in temporal artery implants (TAI) from patients with giant cell arteritis.

Giant cell arteritis (GCA) and Takayasu's disease are inflammatory vasculitic syndromes (IVS) causing sudden blindness and widespread arterial obstruction and aneurysm formation. Glucocorticoids and aspirin are mainstays of treatment, predominantly targeting T cells. Serp-1, a Myxomavirus-deriv...

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Main Authors: Hao Chen, Donghang Zheng, Sriram Ambadapadi, Jennifer Davids, Sally Ryden, Hazem Samy, Mee Bartee, Eric Sobel, Erbin Dai, Liying Liu, Colin Macaulay, Anthony Yachnis, Cornelia Weyand, Robert Thoburn, Alexandra Lucas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4319900?pdf=render

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