Comprehensive methylation analysis of imprinting-associated differentially methylated regions in colorectal cancer

Comprehensive methylation analysis of imprinting-associated differentially methylated regions in colorectal cancer

Abstract Background Imprinted genes are regulated by DNA methylation at imprinting-associated differentially methylated regions (iDMRs). Abnormal expression of imprinted genes is implicated in imprinting disorders and tumors. In colorectal cancer (CRC), methylation and imprinting status of the IGF2/...

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Bibliographic Details
Main Authors: Hidenori Hidaka, Ken Higashimoto, Saori Aoki, Hiroyuki Mishima, Chisa Hayashida, Toshiyuki Maeda, Yasuo Koga, Hitomi Yatsuki, Keiichiro Joh, Hirokazu Noshiro, Ryuichi Iwakiri, Atsushi Kawaguchi, Koh-ichiro Yoshiura, Kazuma Fujimoto, Hidenobu Soejima
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Clinical Epigenetics
Subjects:
Genomic imprinting
DNA methylation
iDMR
CIMP
BRAF mutation
KRAS mutation
Online Access:http://link.springer.com/article/10.1186/s13148-018-0578-9

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