Treatment with a GSK-3β/HDAC Dual Inhibitor Restores Neuronal Survival and Maturation in an In Vitro and In Vivo Model of <i>CDKL5</i> Deficiency Disorder

Treatment with a GSK-3β/HDAC Dual Inhibitor Restores Neuronal Survival and Maturation in an In Vitro and In Vivo Model of <i>CDKL5</i> Deficiency Disorder

Mutations in the X-linked cyclin-dependent kinase-like 5 (<i>CDKL5</i>) gene cause a rare neurodevelopmental disorder characterized by early-onset seizures and severe cognitive, motor, and visual impairments. To date there are no therapies for <i>CDKL5</i> deficiency disorder...

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Bibliographic Details
Main Authors: Manuela Loi, Laura Gennaccaro, Claudia Fuchs, Stefania Trazzi, Giorgio Medici, Giuseppe Galvani, Nicola Mottolese, Marianna Tassinari, Roberto Rimondini Giorgini, Andrea Milelli, Elisabetta Ciani
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
<i>CDKL5</i> deficiency disorder
GSK-3β
HDAC6
dual inhibitor
neuronal survival
hippocampal defects
Online Access:https://www.mdpi.com/1422-0067/22/11/5950

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https://www.mdpi.com/1422-0067/22/11/5950

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