Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future Prospective

Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future Prospective

Vitreoretinal surgeries for ocular diseases such as complicated retinal detachment, diabetic retinopathy, macular holes and ocular trauma has led to the development of various tamponades over the years in search for an ideal vitreous substitute. Current clinically used tamponade agents such as air,...

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Bibliographic Details
Main Authors: Minal Thacker, Ching-Li Tseng, Feng-Huei Lin
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Polymers
Subjects:
vitreous substitute
biopolymer
Online Access:https://www.mdpi.com/2073-4360/13/1/121
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spelling doaj-b54af3d8cb0b4b249a8ffbb4bba4beb42020-12-31T00:04:38ZengMDPI AGPolymers2073-43602021-12-011312112110.3390/polym13010121Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future ProspectiveMinal Thacker0Ching-Li Tseng1Feng-Huei Lin2Graduate Institute of Biomedical Engineering, National Taiwan University, No.49, Fanglan Road, Daan District, Taipei 10051, TaiwanGraduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, No. 250 Wu-Xing Street, Taipei 11031, TaiwanGraduate Institute of Biomedical Engineering, National Taiwan University, No.49, Fanglan Road, Daan District, Taipei 10051, TaiwanVitreoretinal surgeries for ocular diseases such as complicated retinal detachment, diabetic retinopathy, macular holes and ocular trauma has led to the development of various tamponades over the years in search for an ideal vitreous substitute. Current clinically used tamponade agents such as air, perfluorocarbons, silicone oil and expansile gases serve only as a short-term solution and harbors various disadvantages. However, an ideal long-term substitute is yet to be discovered and recent research emphasizes on the potential of polymeric hydrogels as an ideal vitreous substitute. This review highlights the recent progress in the field of vitreous substitution. Suitability and adverse effects of various tamponade agents in present day clinical use and biomaterials in the experimental phase have been outlined and discussed. In addition, we introduced the anatomy and functions of the native vitreous body and the pathological conditions which require vitreous replacement.https://www.mdpi.com/2073-4360/13/1/121vitreous substitutebiopolymer
collection DOAJ
language English
format Article
sources DOAJ
author Minal Thacker
Ching-Li Tseng
Feng-Huei Lin
spellingShingle Minal Thacker
Ching-Li Tseng
Feng-Huei Lin
Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future Prospective
Polymers
vitreous substitute
biopolymer
author_facet Minal Thacker
Ching-Li Tseng
Feng-Huei Lin
author_sort Minal Thacker
title Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future Prospective
title_short Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future Prospective
title_full Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future Prospective
title_fullStr Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future Prospective
title_full_unstemmed Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future Prospective
title_sort substitutes and colloidal system for vitreous replacement and drug delivery: recent progress and future prospective
publisher MDPI AG
series Polymers
issn 2073-4360
publishDate 2021-12-01
description Vitreoretinal surgeries for ocular diseases such as complicated retinal detachment, diabetic retinopathy, macular holes and ocular trauma has led to the development of various tamponades over the years in search for an ideal vitreous substitute. Current clinically used tamponade agents such as air, perfluorocarbons, silicone oil and expansile gases serve only as a short-term solution and harbors various disadvantages. However, an ideal long-term substitute is yet to be discovered and recent research emphasizes on the potential of polymeric hydrogels as an ideal vitreous substitute. This review highlights the recent progress in the field of vitreous substitution. Suitability and adverse effects of various tamponade agents in present day clinical use and biomaterials in the experimental phase have been outlined and discussed. In addition, we introduced the anatomy and functions of the native vitreous body and the pathological conditions which require vitreous replacement.
topic vitreous substitute
biopolymer
url https://www.mdpi.com/2073-4360/13/1/121
work_keys_str_mv AT minalthacker substitutesandcolloidalsystemforvitreousreplacementanddrugdeliveryrecentprogressandfutureprospective
AT chinglitseng substitutesandcolloidalsystemforvitreousreplacementanddrugdeliveryrecentprogressandfutureprospective
AT fenghueilin substitutesandcolloidalsystemforvitreousreplacementanddrugdeliveryrecentprogressandfutureprospective
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