Fulminant Rhizomucor pusillus mucormycosis during anti-leukemic treatment with blinatumomab in a child: A case report and review of the literature

Fulminant Rhizomucor pusillus mucormycosis during anti-leukemic treatment with blinatumomab in a child: A case report and review of the literature

This is the first published case report of a child with acute lymphatic leukemia developing a fatal mucormycosis during blinatumomab treatment. The patient showed multiple, systemic thromboembolic lesions with ischemia, bleeding and infarction in almost all organs. The child succumbed to increased b...

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Main Authors: Sarah Schober, Karin Melanie Cabanillas Stanchi, Anna Riecker, Matthias Pfeiffer, Ilias Tsiflikas, Gesa Wiegand, Leticia Quintanilla-Martinez, Susanne Haen, Martin Ebinger, Peter Lang, Rupert Handgretinger, Michaela Döring
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Medical Mycology Case Reports
Subjects:
Mucormycosis
Pediatric patients
Rhizomucor pusillus
Acute lymphoblastic leukemia relapse
Allogeneic hematopoietic stem cell transplantation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211753920300658
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spelling doaj-b53d3d1ba3d747378cff1a332b78aa412021-05-28T05:01:24ZengElsevierMedical Mycology Case Reports2211-75392021-06-013249Fulminant Rhizomucor pusillus mucormycosis during anti-leukemic treatment with blinatumomab in a child: A case report and review of the literatureSarah Schober0Karin Melanie Cabanillas Stanchi1Anna Riecker2Matthias Pfeiffer3Ilias Tsiflikas4Gesa Wiegand5Leticia Quintanilla-Martinez6Susanne Haen7Martin Ebinger8Peter Lang9Rupert Handgretinger10Michaela Döring11University Children's Hospital Tuebingen, Department I – General Pediatrics, Hematology/Oncology, Hoppe-Seyler-Str.1, 72076, Tuebingen, GermanyUniversity Children's Hospital Tuebingen, Department I – General Pediatrics, Hematology/Oncology, Hoppe-Seyler-Str.1, 72076, Tuebingen, GermanyUniversity Children's Hospital Tuebingen, Department I – General Pediatrics, Hematology/Oncology, Hoppe-Seyler-Str.1, 72076, Tuebingen, GermanyUniversity Children's Hospital Tuebingen, Department I – General Pediatrics, Hematology/Oncology, Hoppe-Seyler-Str.1, 72076, Tuebingen, GermanyDepartment of Diagnostic and Interventional Radiology, University Hospital Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tuebingen, GermanyUniversity Children's Hospital Tuebingen, Department II – Pediatric Cardiology, Intensive Care Medicine and Pulmonology, Hoppe-Seyler-Str. 3, 72076, Tuebingen, GermanyInstitute of Pathology and Neuropathology and Comprehensive Cancer Centre, University Hospital Tuebingen, Liebermeister-Str. 8, 72076, Tuebingen, GermanyInstitute of Pathology and Neuropathology and Comprehensive Cancer Centre, University Hospital Tuebingen, Liebermeister-Str. 8, 72076, Tuebingen, GermanyUniversity Children's Hospital Tuebingen, Department I – General Pediatrics, Hematology/Oncology, Hoppe-Seyler-Str.1, 72076, Tuebingen, GermanyUniversity Children's Hospital Tuebingen, Department I – General Pediatrics, Hematology/Oncology, Hoppe-Seyler-Str.1, 72076, Tuebingen, GermanyUniversity Children's Hospital Tuebingen, Department I – General Pediatrics, Hematology/Oncology, Hoppe-Seyler-Str.1, 72076, Tuebingen, GermanyUniversity Children's Hospital Tuebingen, Department I – General Pediatrics, Hematology/Oncology, Hoppe-Seyler-Str.1, 72076, Tuebingen, Germany; Corresponding author.This is the first published case report of a child with acute lymphatic leukemia developing a fatal mucormycosis during blinatumomab treatment. The patient showed multiple, systemic thromboembolic lesions with ischemia, bleeding and infarction in almost all organs. The child succumbed to increased brain pressure resulting in cerebral herniation. This case particularly illustrates the fulminant progression and huge challenges of diagnosing and treating mucormycosis in children with hemato-oncological diseases during treatment with targeted therapeutic antibodies (blinatumomab).http://www.sciencedirect.com/science/article/pii/S2211753920300658MucormycosisPediatric patientsRhizomucor pusillusAcute lymphoblastic leukemia relapseAllogeneic hematopoietic stem cell transplantation
collection DOAJ
language English
format Article
sources DOAJ
author Sarah Schober
Karin Melanie Cabanillas Stanchi
Anna Riecker
Matthias Pfeiffer
Ilias Tsiflikas
Gesa Wiegand
Leticia Quintanilla-Martinez
Susanne Haen
Martin Ebinger
Peter Lang
Rupert Handgretinger
Michaela Döring
spellingShingle Sarah Schober
Karin Melanie Cabanillas Stanchi
Anna Riecker
Matthias Pfeiffer
Ilias Tsiflikas
Gesa Wiegand
Leticia Quintanilla-Martinez
Susanne Haen
Martin Ebinger
Peter Lang
Rupert Handgretinger
Michaela Döring
Fulminant Rhizomucor pusillus mucormycosis during anti-leukemic treatment with blinatumomab in a child: A case report and review of the literature
Medical Mycology Case Reports
Mucormycosis
Pediatric patients
Rhizomucor pusillus
Acute lymphoblastic leukemia relapse
Allogeneic hematopoietic stem cell transplantation
author_facet Sarah Schober
Karin Melanie Cabanillas Stanchi
Anna Riecker
Matthias Pfeiffer
Ilias Tsiflikas
Gesa Wiegand
Leticia Quintanilla-Martinez
Susanne Haen
Martin Ebinger
Peter Lang
Rupert Handgretinger
Michaela Döring
author_sort Sarah Schober
title Fulminant Rhizomucor pusillus mucormycosis during anti-leukemic treatment with blinatumomab in a child: A case report and review of the literature
title_short Fulminant Rhizomucor pusillus mucormycosis during anti-leukemic treatment with blinatumomab in a child: A case report and review of the literature
title_full Fulminant Rhizomucor pusillus mucormycosis during anti-leukemic treatment with blinatumomab in a child: A case report and review of the literature
title_fullStr Fulminant Rhizomucor pusillus mucormycosis during anti-leukemic treatment with blinatumomab in a child: A case report and review of the literature
title_full_unstemmed Fulminant Rhizomucor pusillus mucormycosis during anti-leukemic treatment with blinatumomab in a child: A case report and review of the literature
title_sort fulminant rhizomucor pusillus mucormycosis during anti-leukemic treatment with blinatumomab in a child: a case report and review of the literature
publisher Elsevier
series Medical Mycology Case Reports
issn 2211-7539
publishDate 2021-06-01
description This is the first published case report of a child with acute lymphatic leukemia developing a fatal mucormycosis during blinatumomab treatment. The patient showed multiple, systemic thromboembolic lesions with ischemia, bleeding and infarction in almost all organs. The child succumbed to increased brain pressure resulting in cerebral herniation. This case particularly illustrates the fulminant progression and huge challenges of diagnosing and treating mucormycosis in children with hemato-oncological diseases during treatment with targeted therapeutic antibodies (blinatumomab).
topic Mucormycosis
Pediatric patients
Rhizomucor pusillus
Acute lymphoblastic leukemia relapse
Allogeneic hematopoietic stem cell transplantation
url http://www.sciencedirect.com/science/article/pii/S2211753920300658
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