Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist

Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist

Glucagon secretion dysregulation in diabetes fosters hyperglycemia. Recent studies report that mice lacking glucagon receptor (Gcgr-/-) do not develop diabetes following streptozotocin (STZ)-mediated ablation of insulin-producing β-cells. Here, we show that diabetes prevention in STZ-treated Gcgr-/-...

Full description

Bibliographic Details
Main Authors: Nicolas Damond, Fabrizio Thorel, Julie S Moyers, Maureen J Charron, Patricia M Vuguin, Alvin C Powers, Pedro L Herrera
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-04-01
Series:eLife
Subjects:
glucagon
glucagon receptor
insulin
type 1 diabetes
hyperglycemia
glucose homeostasis
Online Access:https://elifesciences.org/articles/13828

Similar Items

Similar Items