Cis and trans effects differentially contribute to the evolution of promoters and enhancers

Cis and trans effects differentially contribute to the evolution of promoters and enhancers

Abstract Background Gene expression differences between species are driven by both cis and trans effects. Whereas cis effects are caused by genetic variants located on the same DNA molecule as the target gene, trans effects are due to genetic variants that affect diffusible elements. Previous studie...

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Bibliographic Details
Main Authors: Kaia Mattioli, Winona Oliveros, Chiara Gerhardinger, Daniel Andergassen, Philipp G. Maass, John L. Rinn, Marta Melé
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Genome Biology
Subjects:
Regulatory element evolution
Gene expression evolution
Massively parallel reporter assays
Cis and trans effects
Online Access:http://link.springer.com/article/10.1186/s13059-020-02110-3

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http://link.springer.com/article/10.1186/s13059-020-02110-3

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