PCOS patients; how the endometrium can be ready for frozen embryo transfer? A retrospective study

• Main Authors: Alaa Wageh, Muhammad Fawzy
• Format: Article
• Language: English
• Published: SpringerOpen 2018-12-01
• Series: Middle East Fertility Society Journal
• Online Access: http://www.sciencedirect.com/science/article/pii/S1110569018300530

Study objective: Frozen-thawed embryo transfer (FET) avoids the nightmare of developing ovarian hyperstimulation syndrome in PCOS patients during IVF. Ideal protocols of Endometrium preparation in PCOS patients are lacking and need further declaration. Design: This was a retrospective study of frozen-thawed ET of PCOS Patients who had previously undergone ICSI with cryopreservation. Materials and methods: We compared the pregnancy outcomes from two separate protocols for endometrial preparation in PCOS patients. Cases had pituitary downregulation prior to hormone replacement (n = 37 cycles or patients), and patients hormone replacement without prior downregulation (n = 58 cycles or patients controls). Main outcome measures: Chemical pregnancy rate for downregulation was 56.8% and that of the hormone replacement rate was 55.2%. The clinical pregnancy rate for downregulation was 51.4% vs 50.0% for hormone replacement with no statistically different. Conclusions: In PCOS patients, GnRH downregulation before artificial hormonal treatment in FET didn’t increase the chemical pregnancy and clinical pregnancy, however, this need to be validated in larger prospective randomized studies. Keywords: Frozen-thawed embryo transfer, Polycystic ovary syndrome, Endometrial preparation, GnRH