C-SVR Crispr: Prediction of CRISPR/Cas12 guideRNA activity using deep learning models

C-SVR Crispr: Prediction of CRISPR/Cas12 guideRNA activity using deep learning models

Clustered regularly interspaced short palindromic repeat (CRISPR) technology is the most important tool in gene editing, it can be used to target any gene using guide RNA and Cas enzyme, one limitation of CRISPR systems is low guide RNA (gRNA) activity, therefore it is highly important to predict it...

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Bibliographic Details
Main Authors: Zubaida Sa'id Ameen, Mehmet Ozsoz, Auwalu Saleh Mubarak, Fadi Al Turjman, Sertan Serte
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Alexandria Engineering Journal
Subjects:
CRISPR
Guide RNA activity
COVID-19
Indel frequency
Deep learning
Convolutional Neural Network
Online Access:http://www.sciencedirect.com/science/article/pii/S1110016821000788

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