Correlation between deletion of the CDKN2 gene and tyrosine kinase inhibitor resistance in adult Philadelphia chromosome-positive acute lymphoblastic leukemia

Correlation between deletion of the CDKN2 gene and tyrosine kinase inhibitor resistance in adult Philadelphia chromosome-positive acute lymphoblastic leukemia

Abstract Background Frequency relapses are common in Philadelphia chromosome-positive (Ph-positive) acute lymphoblastic leukemia (ALL) following tyrosine kinase inhibitors (TKIs). CDKN2A/B is believed to contribute to this chemotherapy resistance. Methods To further investigate the association betwe...

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Bibliographic Details
Main Authors: Na Xu, Yu-ling Li, Xuan Li, Xuan Zhou, Rui Cao, Huan Li, Lin Li, Zi-yuan Lu, Ji-xian Huang, Zhi-ping Fan, Fen Huang, Hong-sheng Zhou, Song Zhang, Zhi Liu, Hong-qian Zhu, Qi-fa Liu, Xiao-li Liu
Format: Article
Language:English
Published: BMC 2016-04-01
Series:Journal of Hematology & Oncology
Subjects:
CDKN2
Acute lymphoblastic leukemia
CD20
Philadelphia chromosome
Tyrosine kinase inhibitors
Deletion
Online Access:http://link.springer.com/article/10.1186/s13045-016-0270-5

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