Differences between germline and somatic mutation rates in humans and mice

Germline mutation rates are known to vary between species but somatic mutation rates are less well understood. Here the authors compare mice and humans, observing that somatic mutation rates were nearly two orders of magnitude higher in both species, with both mutation rates significantly higher in...

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Main Authors:	Brandon Milholland, Xiao Dong, Lei Zhang, Xiaoxiao Hao, Yousin Suh, Jan Vijg
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms15183

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spelling	doaj-b50c6055bb5443b5b82b34bb85df6d8b2021-05-11T07:31:44ZengNature Publishing GroupNature Communications2041-17232017-05-01811810.1038/ncomms15183Differences between germline and somatic mutation rates in humans and miceBrandon Milholland0Xiao Dong1Lei Zhang2Xiaoxiao Hao3Yousin Suh4Jan Vijg5Department of Genetics, Albert Einstein College of MedicineDepartment of Genetics, Albert Einstein College of MedicineDepartment of Genetics, Albert Einstein College of MedicineDepartment of Genetics, Albert Einstein College of MedicineDepartment of Genetics, Albert Einstein College of MedicineDepartment of Genetics, Albert Einstein College of MedicineGermline mutation rates are known to vary between species but somatic mutation rates are less well understood. Here the authors compare mice and humans, observing that somatic mutation rates were nearly two orders of magnitude higher in both species, with both mutation rates significantly higher in mice.https://doi.org/10.1038/ncomms15183
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Brandon Milholland Xiao Dong Lei Zhang Xiaoxiao Hao Yousin Suh Jan Vijg
spellingShingle	Brandon Milholland Xiao Dong Lei Zhang Xiaoxiao Hao Yousin Suh Jan Vijg Differences between germline and somatic mutation rates in humans and mice Nature Communications
author_facet	Brandon Milholland Xiao Dong Lei Zhang Xiaoxiao Hao Yousin Suh Jan Vijg
author_sort	Brandon Milholland
title	Differences between germline and somatic mutation rates in humans and mice
title_short	Differences between germline and somatic mutation rates in humans and mice
title_full	Differences between germline and somatic mutation rates in humans and mice
title_fullStr	Differences between germline and somatic mutation rates in humans and mice
title_full_unstemmed	Differences between germline and somatic mutation rates in humans and mice
title_sort	differences between germline and somatic mutation rates in humans and mice
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-05-01
description	Germline mutation rates are known to vary between species but somatic mutation rates are less well understood. Here the authors compare mice and humans, observing that somatic mutation rates were nearly two orders of magnitude higher in both species, with both mutation rates significantly higher in mice.
url	https://doi.org/10.1038/ncomms15183
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Differences between germline and somatic mutation rates in humans and mice

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