Exogenous Asymmetric Dimethylarginine (ADMA) in Pathogenesis of Ischemia-Reperfusion-Induced Gastric Lesions: Interaction with Protective Nitric Oxide (NO) and Calcitonin Gene-Related Peptide (CGRP)

Exogenous Asymmetric Dimethylarginine (ADMA) in Pathogenesis of Ischemia-Reperfusion-Induced Gastric Lesions: Interaction with Protective Nitric Oxide (NO) and Calcitonin Gene-Related Peptide (CGRP)

Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide (NO) synthesis inhibitor and pro-inflammatory factor. We investigated the role of ADMA in rat gastric mucosa compromised through 30 min of gastric ischemia (I) and 3 h of reperfusion (R). These I/R animals were pretreated with ADMA wit...

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Bibliographic Details
Main Authors: Marcin Magierowski, Katarzyna Jasnos, Zbigniew Sliwowski, Marcin Surmiak, Gracjana Krzysiek-Maczka, Agata Ptak-Belowska, Slawomir Kwiecien, Tomasz Brzozowski
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:International Journal of Molecular Sciences
Subjects:
asymmetric dimethyl arginine
gastric mucosa
ischemia/reperfusion
farnesoid X receptor
gastric damage
sensory neurons
calcitonin gene-related peptide
capsaicin
Online Access:http://www.mdpi.com/1422-0067/15/3/4946

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http://www.mdpi.com/1422-0067/15/3/4946

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