Cryptococcus neoformans Glucuronoxylomannan and Sterylglucoside Are Required for Host Protection in an Animal Vaccination Model
The number of deaths from cryptococcal meningitis is around 180,000 per year. The disease is the second leading cause of mortality among individuals with AIDS. Antifungal treatment is costly and associated with adverse effects and resistance, evidencing the urgency of development of both therapeutic...
Main Authors: | Ana Caroline Colombo, Antonella Rella, Tyler Normile, Luna S. Joffe, Patricia M. Tavares, Glauber R. de S. Araújo, Susana Frases, Erika P. Orner, Amir M. Farnoud, Bettina C. Fries, Brian Sheridan, Leonardo Nimrichter, Marcio L. Rodrigues, Maurizio Del Poeta |
---|---|
Format: | Article |
Language: | English |
Published: |
American Society for Microbiology
2019-04-01
|
Series: | mBio |
Subjects: | |
Online Access: | https://doi.org/10.1128/mBio.02909-18 |
Similar Items
-
Cryptococcus neoformans Δsgl1 Vaccination Requires Either CD4+ or CD8+ T Cells for Complete Host Protection
by: Tyler G. Normile, et al.
Published: (2021-09-01) -
Evasion of innate immune responses by the highly virulent Cryptococcus gattii by altering capsule glucuronoxylomannan structure
by: Makoto eUrai, et al.
Published: (2016-01-01) -
Immunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformans
by: Debora Decote-Ricardo, et al.
Published: (2019-06-01) -
In good company: association between fungal glycans generates molecular complexes with unique functions
by: Marcio eRodrigues, et al.
Published: (2012-07-01) -
A Novel, Inexpensive In-House Immunochromatographic Strip Test for Cryptococcosis Based on the Cryptococcal Glucuronoxylomannan Specific Monoclonal Antibody 18B7
by: Pakornswit Sathongdejwisit, et al.
Published: (2021-04-01)