Succinate accumulation induces mitochondrial reactive oxygen species generation and promotes status epilepticus in the kainic acid rat model

Succinate accumulation induces mitochondrial reactive oxygen species generation and promotes status epilepticus in the kainic acid rat model

Though succinate accumulation is associated with reactive oxygen species (ROS) production and neuronal injury, which play critical roles in epilepsy, it is unclear whether succinate accumulation contributes to the onset of epilepsy or seizures. We sought to investigate changes in succinate, oxidativ...

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Bibliographic Details
Main Authors:	Yurong Zhang, Mengdi Zhang, Wei Zhu, Jie Yu, Qiaoyun Wang, Jinjin Zhang, Yaru Cui, Xiaohong Pan, Xue Gao, Hongliu Sun
Format:	Article
Language:	English
Published:	Elsevier 2020-01-01
Series:	Redox Biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231719311425

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